Research Interests

Our current research interests include:

  • Detecting early brain network changes in preclinical and clinical neuropsychiatric disorders such as Alzheimer’s disease and psychosis
  • Understand the neurophysiological signatures and behavioral relevance of dynamic brain functional connectivity
  • Examine the longitudinal brain network changes and its associations in the developing and ageing brain
  • Investigate the underlying neural mechanism of brain-computer interface-based intervention
  • Examine the influence of amyloid-beta and tau on functional and structural connectivity changes in health and disease
  • Develop machine learning and statistical methods for brain-behavior associations


--------------------------------------2018 June--------------------------------

OHBM 2018 will be held in Singapre on June 17-21th, 2018. For more information, cheack out the OHBM official website

Also, for the convenience of OHBM attendees, the Singapore LOC has created a website, please take a look at

--------------------------------------2018 March--------------------------------

Jointly organized by YLL School of Medicine and Duke-NUS Medical School, National University of Singapore, the symposium on biomarkers in dementia will be held at Duke-NUS Medical School on 15-16th, Match, 2018. Where Dr Helen Zhou will give a welcome speech and our lab members will give presentations.

--------------------------------------2018 Feburary--------------------------------

Welcome Professor Xi-Nian Zuo for his visit to Duke-NUS Medical School and sharing his Chinese Color Nest Project - Growing up in China.

Click here for more details:

--------------------------------------2018 Feburary--------------------------------

Welcome Professor Stephen Wood for his visit to Duke-NUS Medical School and discussion on autism and schizophrenia spectrum disoders.

Click here for more details:

--------------------------------------2017 August--------------------------------

Congratulations to Joanna's recent publication "Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer’s disease" has been selected as an Editor's Choice for the month of November 2017, and it will be highlighted on the brain website

Click here for more details:

---------------------------------------2017 June----------------------------------

Congratulations to Joanna and Ashwati for winning the Merit Abstract Award and to Joanna for her presentation well done at OHBM 2017, in Vancouver.

-----------------------------------------2017 May----------------------------------

Congratulations to Dr. Wang Chenhao for winning the Most Outstanding Graduating Duke-NUS M.D./Ph.D. Student award on his thesis "Topology and dynamic of brain intrinsic connectivity in neuropsychiatric disorders".

Journal Club

Our journal club meetings are held every Thursday 9am, Duke-NUS Medical School.

Click here for the JC Venue, Topic, and Speaker

Research Software

FreeSurfer Software Suite

An open source software suite for processing and analyzing (human) brain MRI images.

SPM software package

Designed for the analysis of brain imaging data sequences. The sequences can be a series of images from different cohorts, or time-series from the same subject. The current release is designed for the analysis of fMRI, PET, SPECT, EEG and MEG.


A MATLAB toolbox which implements multiple algorithms for independent component analysis and blind source separation of group (and single subject) functional magnetic resonance imaging data.


A versatile resource program developed for diffusion tensor image (DTI) computation and fiber tracking.

Matlab Psychophysics toolbox

Psychophysics Toolbox Version 3 (PTB-3) is a free set of Matlab and GNU Octave functions for vision and neuroscience research. It synthesizes and shows accurately controlled visual and auditory stimuli for the observer.


A program that allows viewing 3D cortical surface models, and mapping volumetric data onto them.


A toolbox for SPM which provides routines for region of interest analysis.


Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) is a source of neuroinformatics tools, publicly available data sets, and a cloud computing environment.


A cross-platform NIfTI format image viewer.

Brain Connectivity Toolbox

A MATLAB toolbox for complex-network analysis of structural and functional brain-connectivity data sets.


FMRIB Software Library (FSL) is a library of analysis tools for FMRI, MRI and DTI brain imaging data.


Pipeline for analyzing brain diffusion images (PANDA) is a Matlab toolbox for pipeline processing of diffusion MRI images. For each subject, PANDA can provide outputs in 2 types: i) diffusion parameter data that is ready for statistical analysis; ii) brain anatomical networks constructed by using diffusion tractography.


Mainly an EEG, ERP and inverse solutions tool, with some fast and powerful 3D display capabilities.


Resting-State fMRI Data Analysis Toolkit (REST) is a convenient toolkit to calculate Functional Connectivity (FC), Regional Homogeneity (ReHo), Amplitude of Low-Frequency Fluctuation (ALFF), Fractional ALFF (fALFF), Gragner causality, degree centrality, voxel-mirrored homotopic connectivity (VMHC) and perform statistical analysis.