Research Interests

Our current research interests include:

  • Detect early brain network changes in preclinical and clinical neuropsychiatric disorders such as Alzheimer’s disease and psychosis
  • Understand the neurophysiological signatures and behavioral relevance of dynamic brain functional connectivity
  • Examine the longitudinal brain network changes and its associations in the developing and ageing brain
  • Investigate the underlying neural mechanism of brain-computer interface-based intervention
  • Examine the influence of amyloid-beta and tau on functional and structural connectivity changes in health and disease
  • Develop machine learning and statistical methods for brain-behavior associations

News

2018

September

September 21-22: 5th Singhealth Duke-NUS Scientific Congress 2018 (Academia, Singapore)

Our PhD student, Ashwati Vipin, presented her work titled "Greater longitudinal white matter microstructure and extracellular free-water changes in healthy elderly APOE4 allele carriers" and was presented with the Best Oral Presentation (Clinical Junior) Award.

Our other PhD student, Joanna Chong, presented a poster titled "Amyloid and cerebrovascular burden influences on longitudinal brain functional connectivity changes in mild cognitive impairment".

For more information, check out the official website: https://www.singhealthacademy.edu.sg/sites/sdc2018/About/Pages/welcome.aspx

July

July 22-26: Alzheimer's Association International Conference 2018 (Chicago, USA)

Our PhD students Ashwati Vipin and Joanna Chong and Post-doctoral researcher Dr Liwen Zhang attended and presented their work. The meeting brings together scientists, clinicians and industry experts on dementia involved in the advancement of dementia research.

Poster Presentations:

1. Dr Liwen Zhang - "Cerebral Microinfarct Influences Structural Network Topology in Alzheimer's Disease and Cognitive Impairment No
                                  Dementia"

2. Joanna Chong - "Amyloid and Cerebrovascular Burden Influences on Longitudinal Brain Functional Connectivity Changes in Mild Cognitive
                                Impairment"

3. Ashwati Vipin- "Greater Longitudinal White Matter Microstructure and Extracellular Free-Water Changes in Healthy Elderly APOE4 Allele
                             Carriers"


June

June 22: Multimodal Neuroimaging for Mental Disorders Workshop 2018 (CeLS auditorium at NUS, Singapore)

Jointly organized by Dr Helen Zhou's lab from Duke-NUS and Dr Thomas Yeo's lab from NUS. This workshop featured cutting-edge multimodal neuroimaging research by local and international speakers on human brain anatomy, function and connectivity, as well as their alterations due to development, aging and mental disorders.

Dr Helen Zhou gave a talk titled "Brain structural and functional network changes in aging and persons at-risk for dementia".

For more information, check out: https://sites.google.com/site/yeoyeo02/MultimodalNeuroimaging2018

June 17-21: Organization for Human Brain Mapping 2018 (Suntec Convention Centre, Singapore)

The OHBM Annual Meeting is the place to learn about the latest international research across modalities in human brain mapping.

Dr Helen Zhou gave a talk titled "Brain Functional Connectivity in Ageing and Neurodegenerative Disorders: From Nodes to Networks".

Our PhD student, Ashwati Vipin, presented her work titled "Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease" and was presented with the Merit Abstract Award. Her findings illustrate distinct network functional connectivity phenotypes underlying cognitive impairment in patients with and without cerebrovascular disease and provide important evidence for the influence of cerebrovascular disease on early structural network disruptions. Her work has been recently published in Alzheimer's Research and Therapy.

The following lab members presented posters:

1. Dr Kwun Kei Ng - Poster No. 2182 "Age‐related alternations in task modulation and rest‐task similarity of the functional connectome"
2. Dr Siwei Liu - Poster No. 1396 "Longitudinal Working Memory Functional Dysconnectivity Reflects Heterogeneity in UHR for Psychosis"
3. Dr Fang Ji - Poster No. 1101 "Differential severity‐dependent contributions of brain abnormalities to memory deficits in the AD"
4. Joanna Chong - Poster No. 1122 "Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease"
5. Xiao Luo - Poster No. 1124 "White Matter Hyperintensities Predicts Progression in Subjective Memory Concern"
6. Ashwati Vipin - Poster No. 1109 "Cerebrovascular disease influences brain network connectivity in prodromal and clinical AD"
                             (OHBM 2018 Merit Abstract Award)

7. Mengjiao Hu - Poster No. 1456 "Differential BOLD fluctuations in brain networks after BCI Training with and without tDCS in Stroke"
8. Dr Liwen Zhang - Poster No. 1104 "Variability Patterns in Amnestic Mild Cognitive Impairment and Alzheimer's Disease"
9. Dr Xing Qian - Poster No. 1770 "BCI‐based intervention re‐normalizes brain functional network topology in children with ADHD"

For more information, check out the OHBM official website: https://www.humanbrainmapping.org/i4a/pages/index.cfm?pageID=3821

For foreign OHBM attendees, additionally check out: http://brain-in-sinc.com/home.html


April

April 4-8: 6th Biennial Schizophrenia International Research Society Conference (Firenze Fiera Congress Center, Florence, Italy)

Dr Helen Zhou gave a talk titled "Brain Functional Connectomics Based on Resting State fMRI: From Nodes to Networks".

Dr Siwei Liu presented a poster titled "Longitudinal Working Memory Functional Dsyconnectivity Reflects Heterogeneity in Individuals at Ultra High Risk for Psychosis".

For more information, check out the SNR official website: http://www.schizophreniaconference.org/

March

March 19-23: XXI Symposium Neuroradiologicum (Taipei International Convention Center, Taipei, Taiwan)

Dr Helen Zhou gave a talk titled "Longitudinal Brain Structural and Functional Network Changes in Ageing and Neurodegenerative Disorders".

For more information, check out the SNR official website: http://www.snr2018.org/

March 15-16: Biomarkers in Dementia and Cognitive Impairment Symposium (Duke-NUS medical School, Singapore)

Dr Helen Zhou gave a talk titled "Network-based brain structural & functional changes from preclinical to clinical neurodegenerative disorders".

The following presentations were also given by our lab members:

1. Dr Kwun Kei Ng - "Longitudinal changes in brain functional connectivity in healthy older adults and the influence of APOE e4 genotype"
2. Dr Siwei Liu - "The association between retinal neuronal layer and brain structure is disrupted in patients with cognitive impairment and                             Alzheimer’s disease"
3. Dr Fang Ji - "White matter extracellular water increases and tissue damage in the prodromal and clinical Alzheimer’s disease"
4. Joanna Chong - "Influence of Alzheimer's disease and cerebrovascular disease on brain functional networks"
5. Xiao Luo - "Predictive brain structure, amyloid and behavioural features for clinical progression in subjective memory concern"


February

A warm welcome to Professor Xi-Nian Zuo for his visit to Duke-NUS Medical School and sharing his Chinese Color Nest Project - Growing up in China.

Click here for more details: https://www.duke-nus.edu.sg/nbd/event/invited-speaker-seminar-chinese-color-nest-project-growing-china

A warm welcome to Professor Stephen Wood for his visit to Duke-NUS Medical School and discussion on autism and schizophrenia spectrum disoders.

Click here for more details: https://www.duke-nus.edu.sg/nbd/event/invited-speaker-seminar-imaging-cognitive-evidence-diametric-model-autism-and-schizophrenia

2017

August

Congratulations to our PhD student Joanna Chong's recent publication "Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer’s disease" has been selected as an Editor's Choice for the month of November 2017, and it will be highlighted on the brain website https://academic.oup.com/brain.

Click here for more details: https://www.duke-nus.edu.sg/news/differing-neural-network-responses-alzheimer%E2%80%99s-patients-and-without-cerebrovascular-disease

June

Congratulations to our PhD students Joanna Chong and Ashwati Vipin for winning the Merit Abstract Award and to Joanna for her presentation well done at OHBM 2017, in Vancouver.



May

Congratulations to Dr. Wang Chenhao for winning the Most Outstanding Graduating Duke-NUS M.D./Ph.D. Student award on his thesis "Topology and dynamic of brain intrinsic connectivity in neuropsychiatric disorders".

Journal Club


Our journal club meetings are held every Thursday 9am, Duke-NUS Medical School.

Click here for the JC Venue, Topic, and Speaker

Research Software

FreeSurfer Software Suite

An open source software suite for processing and analyzing (human) brain MRI images.


SPM software package

Designed for the analysis of brain imaging data sequences. The sequences can be a series of images from different cohorts, or time-series from the same subject. The current release is designed for the analysis of fMRI, PET, SPECT, EEG and MEG.


GIFT

A MATLAB toolbox which implements multiple algorithms for independent component analysis and blind source separation of group (and single subject) functional magnetic resonance imaging data.


DTIstudio

A versatile resource program developed for diffusion tensor image (DTI) computation and fiber tracking.


Matlab Psychophysics toolbox

Psychophysics Toolbox Version 3 (PTB-3) is a free set of Matlab and GNU Octave functions for vision and neuroscience research. It synthesizes and shows accurately controlled visual and auditory stimuli for the observer.


SUMA

A program that allows viewing 3D cortical surface models, and mapping volumetric data onto them.


MarsBaR

A toolbox for SPM which provides routines for region of interest analysis.


NITRC

Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) is a source of neuroinformatics tools, publicly available data sets, and a cloud computing environment.


MRIcron

A cross-platform NIfTI format image viewer.


Brain Connectivity Toolbox

A MATLAB toolbox for complex-network analysis of structural and functional brain-connectivity data sets.


FSL

FMRIB Software Library (FSL) is a library of analysis tools for FMRI, MRI and DTI brain imaging data.


PANDA

Pipeline for analyzing brain diffusion images (PANDA) is a Matlab toolbox for pipeline processing of diffusion MRI images. For each subject, PANDA can provide outputs in 2 types: i) diffusion parameter data that is ready for statistical analysis; ii) brain anatomical networks constructed by using diffusion tractography.


EEG-Cartool

Mainly an EEG, ERP and inverse solutions tool, with some fast and powerful 3D display capabilities.


REST

Resting-State fMRI Data Analysis Toolkit (REST) is a convenient toolkit to calculate Functional Connectivity (FC), Regional Homogeneity (ReHo), Amplitude of Low-Frequency Fluctuation (ALFF), Fractional ALFF (fALFF), Gragner causality, degree centrality, voxel-mirrored homotopic connectivity (VMHC) and perform statistical analysis.